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Hamel, Anne-Laure; Delbos, Léo; Natella, Pierre-André; Radulesco, Thomas; Alexandru, Mihaela; Bartaire, Emmanuel; Bartier, Sophie; Benoite, Gonda; Bequignon, Emilie; Castillo, Laurent; Canouï-Poitrine, Florence; Carsuzaa, Florent; Corré, Alain; Coste, André; Couloigner, Vincent; Daveau, Clémentine; De Boissieu, Paul; De Bonnecaze, Guillaume; De Gabory, Ludovic; Debry, Christian; Deraedt, Simon; Dufour, Xavier; El Bakkouri, Wissame; Gilain, Laurent; [...]

The Prognostic Value of Olfactory Dysfunction in Patients with COVID-19: The COVIDORA Study

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  • Medientyp: E-Artikel
  • Titel: The Prognostic Value of Olfactory Dysfunction in Patients with COVID-19: The COVIDORA Study
  • Beteiligte: Hamel, Anne-Laure; Delbos, Léo; Natella, Pierre-André; Radulesco, Thomas; Alexandru, Mihaela; Bartaire, Emmanuel; Bartier, Sophie; Benoite, Gonda; Bequignon, Emilie; Castillo, Laurent; Canouï-Poitrine, Florence; Carsuzaa, Florent; Corré, Alain; Coste, André; Couloigner, Vincent; Daveau, Clémentine; De Boissieu, Paul; De Bonnecaze, Guillaume; De Gabory, Ludovic; Debry, Christian; Deraedt, Simon; Dufour, Xavier; El Bakkouri, Wissame; Gilain, Laurent; [...]
  • Erschienen: MDPI AG, 2024
  • Erschienen in: Life
  • Sprache: Englisch
  • DOI: 10.3390/life14030293
  • ISSN: 2075-1729
  • Schlagwörter: Paleontology ; Space and Planetary Science ; General Biochemistry, Genetics and Molecular Biology ; Ecology, Evolution, Behavior and Systematics
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>Background: Among all studies describing COVID-19 clinical features during the first wave of the pandemic, only a few retrospective studies have assessed the correlation between olfac-tory dysfunction (OD) and the evolution of disease severity. The main aim was to assess whether OD is a predictive factor of COVID-19 severity based on the patient’s medical management (outpa-tient care, standard hospital admission, and ICU admission). Methods: A national, prospective, mul-ticenter cohort study was conducted in 20 public hospitals and a public center for COVID-19 screen-ing. During the first wave of the pandemic, from 6 April to 11 May 2020, all patients tested positive for COVID-19 confirmed by RT-PCR underwent two follow-up ENT consultations within 10 days of symptom onset. The main outcome measures were the evolution of medical management (out-patient care, standard hospital admission, and ICU admission) at diagnosis and along the clinical course of COVID-19 disease. Results: Among 481 patients included, the prevalence of OD was 60.7%, and it affected mostly female patients (74.3%) under 65 years old (92.5%), with fewer comor-bidities than patients with normal olfactory function. Here, 99.3% (290/292) of patients with OD presented with non-severe COVID-19 disease. Patients reporting OD were significantly less hospi-talized than the ones managed as outpatients, in either a standard medical unit or an ICU. Conclu-sions: As regards the clinical course of COVID-19 disease, OD could predict a decreased risk of hospitalization during the first wave of the pandemic.</jats:p>
  • Zugangsstatus: Freier Zugang