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Malagnino, Vincenzo; Teti, Elisabetta; Compagno, Mirko; Coppola, Luigi; Salpini, Romina; Svicher, Valentina; Basso, Monica; Battagin, Giuliana; Panese, Sandro; Rossi, Maria Cristina; Scaggiante, Renzo; Zago, Daniela; Iannetta, Marco; Parisi, Saverio Giuseppe; Andreoni, Massimo; Sarmati, Loredana

HBcAb Positivity Is a Risk Factor for an Increased Detectability of HIV RNA after Switching to a Two-Drug Regimen Lamivudine-Based (2DR-3TC-Based) Treatment: Analysis of a Multicenter Italian Cohort

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  • Medientyp: E-Artikel
  • Titel: HBcAb Positivity Is a Risk Factor for an Increased Detectability of HIV RNA after Switching to a Two-Drug Regimen Lamivudine-Based (2DR-3TC-Based) Treatment: Analysis of a Multicenter Italian Cohort
  • Beteiligte: Malagnino, Vincenzo; Teti, Elisabetta; Compagno, Mirko; Coppola, Luigi; Salpini, Romina; Svicher, Valentina; Basso, Monica; Battagin, Giuliana; Panese, Sandro; Rossi, Maria Cristina; Scaggiante, Renzo; Zago, Daniela; Iannetta, Marco; Parisi, Saverio Giuseppe; Andreoni, Massimo; Sarmati, Loredana
  • Erschienen: MDPI AG, 2021
  • Erschienen in: Microorganisms
  • Sprache: Englisch
  • DOI: 10.3390/microorganisms9020396
  • ISSN: 2076-2607
  • Schlagwörter: Virology ; Microbiology (medical) ; Microbiology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>The aim of this study was to evaluate whether the presence of anti-hepatitis B (HBV) c antibodies (HBcAb positivity) could influence the control of Human Immunodeficiency Virus (HIV) viremia in patients living with HIV (PLWH) who switch a to two-drug antiretroviral therapy (2DR) containing lamivudine (3TC) (2DR-3TC). A retrospective observational multicenter study was conducted on 166 PLWH switching to the 2DR-3TC-based regimen: 58 HBcAb-positive and 108 HBcAb-negative patients. The HBcAb-positive PLWH group demonstrated a significantly higher percentage of subjects with very low-level viremia at all time points after switching (6th month: &lt;31% vs. 17.6%, p = 0.047; 12th month 34% vs. 27.5%, p = 0.001; 24th month 37% vs. 34.2, p = 0.003 of the HBcAb-positive and HBcAb-negative groups, respectively) and a higher percentage of subjects with detectable HIV RNA greater than 20 copies/mL 12 and 24 months after switching (12 months 32% vs. 11%, p = 0.001; 24 months 37% vs. 13.9%, p = 0.003 of the HBcAb-positive and HBcAb-negative groups, respectively). Logistic regression analysis showed that an increase in age of ten years (OR 2.48 (95% CI 1.58–3.89), p &lt; 0.0001) and the presence of HBcAb positivity (OR 2.7 (5% CI 1.05–6.9), p = 0.038) increased the risk of detectability of HIV RNA by nearly three-fold after switching to 2DR-3TC.</jats:p>
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