Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata
Beteiligte:
Olmedo, Dionisio A.;
López-Pérez, José L.;
Del Olmo, Esther;
Vásquez, Yelkaira;
San Feliciano, Arturo;
Gupta, Mahabir P.
Erschienen:
MDPI AG, 2008
Erschienen in:
Molecules, 13 (2008) 11, Seite 2915-2924
Sprache:
Englisch
DOI:
10.3390/molecules13112915
ISSN:
1420-3049
Entstehung:
Anmerkungen:
Beschreibung:
Bioassay-guided fractionation of the dichloromethane extract of the leaves of Marila pluricostata led to the isolation of 2α,3β-dihydroxy-D:A-friedoolean-28-oic acid (pluricostatic acid), a new friedelane triterpenoid, (1), ten known triterpenoids and three sterols. Their chemical structures were elucidated through spectroscopic analysis. The less polar fractions, on GC/MS analysis and comparison with a MS library, resulted in the identification of twenty four sesquiterpenoids. The new triterpenoid acid 1 showed cytotoxicity against the MCF-7, H-460, and SF-268 human cancer cell lines with GI50 values from 1.2 to 3.3 μg/mL.