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Medientyp:
E-Artikel
Titel:
Modified Nucleosides, Nucleotides and Nucleic Acids via Click Azide-Alkyne Cycloaddition for Pharmacological Applications
Beteiligte:
Perrone, Daniela;
Marchesi, Elena;
Preti, Lorenzo;
Navacchia, Maria Luisa
Erschienen:
MDPI AG, 2021
Erschienen in:Molecules
Sprache:
Englisch
DOI:
10.3390/molecules26113100
ISSN:
1420-3049
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>The click azide = alkyne 1,3-dipolar cycloaddition (click chemistry) has become the approach of choice for bioconjugations in medicinal chemistry, providing facile reaction conditions amenable to both small and biological molecules. Many nucleoside analogs are known for their marked impact in cancer therapy and for the treatment of virus diseases and new targeted oligonucleotides have been developed for different purposes. The click chemistry allowing the tolerated union between units with a wide diversity of functional groups represents a robust means of designing new hybrid compounds with an extraordinary diversity of applications. This review provides an overview of the most recent works related to the use of click chemistry methodology in the field of nucleosides, nucleotides and nucleic acids for pharmacological applications.</jats:p>