> Detailanzeige

Saka, Saheed Olanrewaju; Salisu, Yusuf Yahaya; Sahabi, Hauwa’u Muhammad; Sanusi, Kamaldeen Olalekan; Ibrahim, Kasimu Ghandi; Abubakar, Murtala Bello; Isa, Suleiman Ahmed; Liman, Muhammad Gidado; Shehu, Sha’aya’u; Malami, Ibrahim; Chan, Kim Wei; Azmi, Nur Hanisah; Imam, Mustapha Umar

Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of Metabolic Disorders in a Fruit Fly Model

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of Metabolic Disorders in a Fruit Fly Model
  • Beteiligte: Saka, Saheed Olanrewaju; Salisu, Yusuf Yahaya; Sahabi, Hauwa’u Muhammad; Sanusi, Kamaldeen Olalekan; Ibrahim, Kasimu Ghandi; Abubakar, Murtala Bello; Isa, Suleiman Ahmed; Liman, Muhammad Gidado; Shehu, Sha’aya’u; Malami, Ibrahim; Chan, Kim Wei; Azmi, Nur Hanisah; Imam, Mustapha Umar
  • Erschienen: MDPI AG, 2023
  • Erschienen in: Molecules, 28 (2023) 2, Seite 532
  • Sprache: Englisch
  • DOI: 10.3390/molecules28020532
  • ISSN: 1420-3049
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Consumption of white rice (WR) has been shown to predispose individuals to metabolic disorders. However, brown rice (BR), which is relatively richer in bioactive compounds, possesses anti-glycaemic and antioxidant effects. In this study, fifteen cultivars of paddy rice that are predominantly consumed in North West Nigeria were analysed for their nutritional composition, bioactive contents and effects on metabolic outcomes in a fruit fly model. Gene expression analyses were conducted on the whole fly, targeting dPEPCK, dIRS, and dACC. The protein, carbohydrate, and fibre contents and bioactives of all BR cultivars were significantly different (p < 0.05) from the WR cultivars. Moreover, it was demonstrated that the glucose and trehalose levels were significantly higher (p < 0.05), while glycogen was significantly lower (p < 0.05) in the WR groups compared to the BR groups. Similarly, the expression of dACC and dPEPCK was upregulated, while that of dIRS was downregulated in the WR groups compared to the BR groups. Sex differences (p < 0.05) were observed in the WR groups in relation to the nutrigenomic effects. Our findings confirm metabolic perturbations in fruit flies following consumption of WR via distortion of insulin signalling and activation of glycogenolysis and gluconeogenesis. BR prevented these metabolic changes possibly due to its richer nutritional composition.
  • Zugangsstatus: Freier Zugang