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Medientyp:
E-Artikel
Titel:
Synthesis and Biological Activity of Chromeno[3,2-c]Pyridines
Beteiligte:
Listratova, Anna V.;
Borisov, Roman S.;
Polovkov, Nikolay Yu.;
Kulikova, Larisa N.
Erschienen:
MDPI AG, 2024
Erschienen in:
Molecules, 29 (2024) 21, Seite 4997
Sprache:
Englisch
DOI:
10.3390/molecules29214997
ISSN:
1420-3049
Entstehung:
Anmerkungen:
Beschreibung:
The review summarizes all synthetic methodologies for the preparation of chromeno[3,2-c]pyridines and chromeno[3,2-c]quinolines. The proposed approaches are systemized based on ways for the construction of the heterocyclic system. The presence of these compounds in nature and their bioactivity are also discussed. Natural products with an annelated chromeno[3,2-c]pyridine fragment are well-known and a number of alkaloids derived from this system as a key core have been recently isolated. These compounds demonstrate antimicrobial, antivirus, and cytotoxic activities, making chromeno[3,2-c]pyridine structural motifs promising for medicinal chemistry.