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Fayol, Laurence; Yaacoub, Jilnar; Baillat, Marine; des Robert, Clotilde; Pauly, Vanessa; Dagau, Gina; Berbis, Julie; Arnaud, Frédérique; Baudesson, Audrey; Brévaut-Malaty, Véronique; Derain-Court, Justine; Desse, Blandine; Fortier, Clara; Mallet, Eric; Ledoyen, Anaïs; Parache, Christelle; Picaud, Jean-Claude; Quetin, Philippe; Richard, Bénédicte; Zoccarato, Anne-Marie; Maillotte, Anne-Marie; Boubred, Farid

Association of Standardized Parenteral Nutrition with Early Neonatal Growth of Moderately Preterm Infants: A Population-Based Cohort Study

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  • Medientyp: E-Artikel
  • Titel: Association of Standardized Parenteral Nutrition with Early Neonatal Growth of Moderately Preterm Infants: A Population-Based Cohort Study
  • Beteiligte: Fayol, Laurence; Yaacoub, Jilnar; Baillat, Marine; des Robert, Clotilde; Pauly, Vanessa; Dagau, Gina; Berbis, Julie; Arnaud, Frédérique; Baudesson, Audrey; Brévaut-Malaty, Véronique; Derain-Court, Justine; Desse, Blandine; Fortier, Clara; Mallet, Eric; Ledoyen, Anaïs; Parache, Christelle; Picaud, Jean-Claude; Quetin, Philippe; Richard, Bénédicte; Zoccarato, Anne-Marie; Maillotte, Anne-Marie; Boubred, Farid
  • Erschienen: MDPI AG, 2024
  • Erschienen in: Nutrients, 16 (2024) 9, Seite 1292
  • Sprache: Englisch
  • DOI: 10.3390/nu16091292
  • ISSN: 2072-6643
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: In preterm infants, early nutrient intake during the first week of life often depends on parenteral nutrition. This study aimed to evaluate the influence of standardized parenteral nutrition using three-in-one double-chamber solutions (3-in-1 STD-PN) on early neonatal growth in a cohort of moderately preterm (MP) infants. This population-based, observational cohort study included preterm infants admitted to neonatal centers in the southeast regional perinatal network in France. During the study period, 315 MP infants with gestational ages between 320/7 and 346/7 weeks who required parenteral nutrition from birth until day-of-life 3 (DoL3) were included; 178 received 3-in-1 STD-PN solution (56.5%). Multivariate regression was used to assess the factors associated with the relative body-weight difference between days 1 and 7 (RBWD DoL1-7). Infants receiving 3-in-1 STD-PN lost 36% less body weight during the first week of life, with median RBWD DoL1-7 of −2.5% vs. −3.9% in infants receiving other PN solutions (p < 0.05). They also received higher parenteral energy and protein intakes during the overall first week, with 85% (p < 0.0001) and 27% (p < 0.0001) more energy and protein on DoL 3. After adjusting for confounding factors, RBWD DoL1-7 was significantly lower in the 3-in-1 STD-NP group than in their counterparts, with beta (standard deviation) = 2.08 (0.91), p = 0.02. The use of 3-in-1 STD-PN provided better energy and protein intake and limited early weight loss in MP infants.
  • Zugangsstatus: Freier Zugang