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Medientyp:
E-Artikel
Titel:
Effects of Periodic Fasting on Fatty Liver Index—A Prospective Observational Study
Beteiligte:
Drinda, Stefan;
Grundler, Franziska;
Neumann, Thomas;
Lehmann, Thomas;
Steckhan, Nico;
Michalsen, Andreas;
Wilhelmi de Toledo, Francoise
Erschienen:
MDPI AG, 2019
Erschienen in:Nutrients
Sprache:
Englisch
DOI:
10.3390/nu11112601
ISSN:
2072-6643
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>This prospective observational trial investigated effects and safety of periodic fasting in subjects with and without type 2 diabetes mellitus (T2DM). The primary end point was set as the change of fatty liver index (FLI) as a surrogate parameter of non-alcoholic fatty liver disease (NAFLD). Six-hundred and ninety-seven subjects (38 with T2DM) were enrolled. A baseline FLI ≥ 60 (the threshold for fatty liver) was found in 264 subjects (37.9%). The mean duration of fasting was 8.5 ± 4.0 days (range 6–38). FLI decreased significantly (−14.02 ± 11.67; p < 0.0001), with a larger effect in individuals with T2DM (−19.15 ± 11.0; p < 0.0001; p = 0.002 compared to non-diabetic subjects). Body mass index (BMI) decreased by −1.51 ± 0.82 kg/m2, and 49.9% of the subjects lost ≥5% body weight. After fasting, nearly half of the 264 subjects with FLI ≥ 60 (highest risk category) shifted to a lower category. The improvement of FLI correlated with the number of fasting days (r = −0.20, p < 0.0001) and with the magnitude of BMI reduction (r = 0.14, p = 0.0001). Periodic fasting with concomitant weight reduction leads to significant rapid improvement of FLI in subjects with and without T2DM.</jats:p>