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Bobik, Tatyana V.; Kostin, Nikita N.; Skryabin, George A.; Tsabai, Polina N.; Simonova, Maria A.; Knorre, Vera D.; Mokrushina, Yuliana A.; Smirnov, Ivan V.; Kosolapova, Julia A.; Vtorushina, Valentina V.; Inviyaeva, Evgeniya V.; Polushkina, Evgeniya; Petrova, Ulyana L.; Levadnaya, Anna V.; Krechetova, Lyubov V.; Shmakov, Roman G.; Sukhikh, Gennadiy T.; Gabibov, Alexander G.

Epitope-Specific Response of Human Milk Immunoglobulins in COVID-19 Recovered Women

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  • Medientyp: E-Artikel
  • Titel: Epitope-Specific Response of Human Milk Immunoglobulins in COVID-19 Recovered Women
  • Beteiligte: Bobik, Tatyana V.; Kostin, Nikita N.; Skryabin, George A.; Tsabai, Polina N.; Simonova, Maria A.; Knorre, Vera D.; Mokrushina, Yuliana A.; Smirnov, Ivan V.; Kosolapova, Julia A.; Vtorushina, Valentina V.; Inviyaeva, Evgeniya V.; Polushkina, Evgeniya; Petrova, Ulyana L.; Levadnaya, Anna V.; Krechetova, Lyubov V.; Shmakov, Roman G.; Sukhikh, Gennadiy T.; Gabibov, Alexander G.
  • Erschienen: MDPI AG, 2021
  • Erschienen in: Pathogens
  • Sprache: Englisch
  • DOI: 10.3390/pathogens10060705
  • ISSN: 2076-0817
  • Schlagwörter: Infectious Diseases ; Microbiology (medical) ; General Immunology and Microbiology ; Molecular Biology ; Immunology and Allergy
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>The breastfeeding of infants by mothers who are infected with SARS-CoV-2 has become a dramatic healthcare problem. The WHO recommends that infected women should not abandon breastfeeding; however, there is still the risk of contact transmission. Convalescent donor milk may provide a defense against the aforementioned issue and can eliminate the consequences of artificial feeding. Therefore, it is vital to characterize the epitope-specific immunological landscape of human milk from women who recovered from COVID-19. We carried out a comprehensive ELISA-based analysis of blood serum and human milk from maternity patients who had recovered from COVID-19 at different trimesters of pregnancy. It was found that patients predominantly contained SARS-CoV-2 N-protein-specific immunoglobulins and had manifested the antibodies for all the antigens tested in a protein-specific and time-dependent manner. Women who recovered from COVID-19 at trimester I–II showed a noticeable decrease in the number of milk samples with sIgA specific to the N-protein, linear NTD, and RBD-SD1 epitopes, and showed an increase in samples with RBD conformation-dependent sIgA. S-antigens were found to solely induce a sIgA1 response, whereas N-protein sIgA1 and sIgA2 subclasses were involved in 100% and 33% of cases. Overall, the antibody immunological landscape of convalescent donor milk suggests that it may be a potential defense agent against COVID-19 for infants, conferring them with a passive immunity.</jats:p>
  • Zugangsstatus: Freier Zugang