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Kronenberg, Philipp A.; Deibel, Ansgar; Gottstein, Bruno; Grimm, Felix; Müllhaupt, Beat; Meyer zu Schwabedissen, Cordula; Aitbaev, Sezdbek; Omorov, Rakhatbek A.; Abdykerimov, Kubanychbek K.; Minbaeva, Gulnara; Usubalieva, Jumagul; Siles-Lucas, Mar; Pepe, Paola; Rinaldi, Laura; Spiliotis, Markus; Wang, Junhua; Müller, Norbert; Torgerson, Paul R.; Deplazes, Peter

Serological Assays for Alveolar and Cystic Echinococcosis—A Comparative Multi-Test Study in Switzerland and Kyrgyzstan

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  • Medientyp: E-Artikel
  • Titel: Serological Assays for Alveolar and Cystic Echinococcosis—A Comparative Multi-Test Study in Switzerland and Kyrgyzstan
  • Beteiligte: Kronenberg, Philipp A.; Deibel, Ansgar; Gottstein, Bruno; Grimm, Felix; Müllhaupt, Beat; Meyer zu Schwabedissen, Cordula; Aitbaev, Sezdbek; Omorov, Rakhatbek A.; Abdykerimov, Kubanychbek K.; Minbaeva, Gulnara; Usubalieva, Jumagul; Siles-Lucas, Mar; Pepe, Paola; Rinaldi, Laura; Spiliotis, Markus; Wang, Junhua; Müller, Norbert; Torgerson, Paul R.; Deplazes, Peter
  • Erschienen: MDPI AG, 2022
  • Erschienen in: Pathogens, 11 (2022) 5, Seite 518
  • Sprache: Englisch
  • DOI: 10.3390/pathogens11050518
  • ISSN: 2076-0817
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Both alveolar (AE) and cystic echinococcosis (CE) are lacking pathognomonic clinical signs; consequently imaging technologies and serology remain the main pillars for diagnosis. The present study included 100 confirmed treatment-naïve AE and 64 CE patients that were diagnosed in Switzerland or Kyrgyzstan. Overall, 10 native Echinococcus spp. antigens, 3 recombinant antigens, and 4 commercial assays were comparatively evaluated. All native E. multilocularis antigens were produced in duplicates with a European and a Kyrgyz isolate and showed identical test values for the diagnosis of AE and CE. Native antigens and three commercial tests showed high diagnostic sensitivities (Se: 86–96%) and specificities (Sp: 96–99%) for the diagnosis of AE and CE in Swiss patients. In Kyrgyz patients, values of sensitivities and specificities were 10–20% lower as compared to the Swiss patients’ findings. For the sero-diagnosis of AE in Kyrgyzstan, a test-combination of an E. multilocularis protoscolex antigen and the recombinant antigen Em95 appears to be the most suitable test strategy (Se: 98%, Sp: 87%). For the diagnosis of CE in both countries, test performances were hampered by major cross-reactions with AE patients and other parasitic diseases as well as by limited diagnostic sensitivities (93% in Switzerland and 76% in Kyrgyzstan, respectively).
  • Zugangsstatus: Freier Zugang