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Coppola, Carmine; Kondili, Loreta A.; Staiano, Laura; Cammarota, Simona; Citarella, Anna; Aloisio, Mirko Pio; Annunziata, Angelo; Bernardi, Francesca Futura; D’Avino, Aldo; D’Orazio, Michele; Fogliasecca, Marianna; Fusco, Mario; Pisano, Federica; Vercellone, Adriano; Bianco, Elvira; Trama, Ugo

Hepatitis C Virus Micro-Elimination Plan in Southern Italy: The “HCV ICEberg” Project

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  • Medientyp: E-Artikel
  • Titel: Hepatitis C Virus Micro-Elimination Plan in Southern Italy: The “HCV ICEberg” Project
  • Beteiligte: Coppola, Carmine; Kondili, Loreta A.; Staiano, Laura; Cammarota, Simona; Citarella, Anna; Aloisio, Mirko Pio; Annunziata, Angelo; Bernardi, Francesca Futura; D’Avino, Aldo; D’Orazio, Michele; Fogliasecca, Marianna; Fusco, Mario; Pisano, Federica; Vercellone, Adriano; Bianco, Elvira; Trama, Ugo
  • Erschienen: MDPI AG, 2023
  • Erschienen in: Pathogens, 12 (2023) 2, Seite 195
  • Sprache: Englisch
  • DOI: 10.3390/pathogens12020195
  • ISSN: 2076-0817
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: This study evaluates the feasibility of a local action program for HCV micro-elimination in highly endemic areas. Retrospective analysis: administrative and laboratory data (Local Health Unit, southern Italy) were integrated to quantize the anti-HCV-positive subjects not RNA tested and untreated HCV-infected subjects (2018–2022). Prospective analysis: all subjects admitted to a division of the LHU largest hospital (2021–2022) were tested for HCV, with linkage of active-infected patients to care. Overall, 49287 subjects were HCV-Ab tested: 1071 (2.2%) resulted positive without information for an HCV RNA test and 230 (0.5%) had an active infection not yet cured. Among 856 admitted subjects, 54 (6.3%) were HCV-Ab+ and 27 (3.0%) HCV RNA+. Of HCV-infected patients, 22.2% had advanced liver disease, highlighting the need for earlier diagnosis; 27.7% were unaware of HCV infection; and 20.4% were previously aware but never referred to a clinical center. Of these, 26% died and 74% received treatment. Our study emphasizes the value of an active HCV hospital case-finding program to enhance diagnosis in patients with several comorbidities and to easily link them to care. Our data strongly suggest extending this program to all hospital wards/access as a standard of care, particularly in highly endemic areas, to help HCV disease control and take steps in achieving the elimination goals.
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