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Medientyp:
E-Artikel
Titel:
Finsler Geometry Modeling of Phase Separation in Multi-Component Membranes
Beteiligte:
Usui, Satoshi;
Koibuchi, Hiroshi
Erschienen:
MDPI AG, 2016
Erschienen in:
Polymers, 8 (2016) 8, Seite 284
Sprache:
Englisch
DOI:
10.3390/polym8080284
ISSN:
2073-4360
Entstehung:
Anmerkungen:
Beschreibung:
A Finsler geometric surface model is studied as a coarse-grained model for membranes of three components, such as zwitterionic phospholipid (DOPC), lipid (DPPC) and an organic molecule (cholesterol). To understand the phase separation of liquid-ordered (DPPC rich) L o and liquid-disordered (DOPC rich) L d , we introduce a binary variable σ ( = ± 1 ) into the triangulated surface model. We numerically determine that two circular and stripe domains appear on the surface. The dependence of the morphological change on the area fraction of L o is consistent with existing experimental results. This provides us with a clear understanding of the origin of the line tension energy, which has been used to understand these morphological changes in three-component membranes. In addition to these two circular and stripe domains, a raft-like domain and budding domain are also observed, and the several corresponding phase diagrams are obtained.