Erschienen in:Beilstein Journal of Organic Chemistry
Sprache:
Englisch
DOI:
10.3762/bjoc.15.136
ISSN:
1860-5397
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>A consecutive three-component activation–alkynylation–cyclization reaction of (hetero)aryl glyoxylic acids, oxalyl chloride, arylacetylenes, and hydrazides efficiently forms 1,5-diacyl-5-hydroxypyrazolines in moderate to good yields. The structures were unambiguously corroborated by comprehensive NMR spectroscopy and X-ray structure analyses of selected derivatives.</jats:p>