• Medientyp: E-Artikel
  • Titel: Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation
  • Beteiligte: Smadhi, Meriem; de Bentzmann, Sophie; Imberty, Anne; Gingras, Marc; Abderrahim, Raoudha; Goekjian, Peter G
  • Erschienen: Beilstein Institut, 2014
  • Erschienen in: Beilstein Journal of Organic Chemistry
  • Sprache: Englisch
  • DOI: 10.3762/bjoc.10.206
  • ISSN: 1860-5397
  • Schlagwörter: Organic Chemistry
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>Readily accessible, low-valency glycoclusters based on a triazine core bearing D-galactose and L-fucose epitopes are able to inhibit biofilm formation by <jats:italic>Pseudomonas aeruginosa</jats:italic>. These multivalent ligands are simple to synthesize, are highly soluble, and can be either homofunctional or heterofunctional. The galactose-decorated cluster shows good affinity for <jats:italic>Pseudomonas aeruginosa</jats:italic> lectin lecA. They are convenient biological probes for investigating the roles of lecA and lecB in biofilm formation.</jats:p>
  • Zugangsstatus: Freier Zugang