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Medientyp:
E-Artikel
Titel:
Cutting Edge: A Novel, Human-Specific Interacting Protein Couples FOXP3 to a Chromatin-Remodeling Complex That Contains KAP1/TRIM28
Beteiligte:
Huang, Chunjian;
Martin, Sunil;
Pfleger, Christian;
Du, Jianguang;
Buckner, Jane H.;
Bluestone, Jeffrey A.;
Riley, James L.;
Ziegler, Steven F.
Erschienen:
The American Association of Immunologists, 2013
Erschienen in:The Journal of Immunology
Sprache:
Englisch
DOI:
10.4049/jimmunol.1203561
ISSN:
0022-1767;
1550-6606
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title>
<jats:p>Regulatory T cells (Tregs) play a pivotal role in the maintenance of immunological self-tolerance. Deficiency or dysfunction of Tregs leads to severe autoimmune diseases. Although the forkhead/winged-helix family member FOXP3 is critical for Treg differentiation and function, the molecular basis for FOXP3 function remains unclear. In this study, we identified and characterized a human-specific FOXP3-interacting protein, referred to as FIK (FOXP3-interacting KRAB domain–containing protein). FIK is highly expressed in Tregs and acts as a bridging molecule to link FOXP3 with the chromatin-remodeling scaffold protein KAP1 (TIF-1β/TRIM28). Disruption of the FOXP3–FIK–KAP1 complex in Tregs restored expression of FOXP3-target genes and abrogated the suppressor activity of the Tregs. These data demonstrate a critical role for FIK in regulating FOXP3 activity and Treg function.</jats:p>