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Medientyp:
E-Artikel
Titel:
Cutting Edge: CD4 T Cell-Mast Cell Interactions Alter IgE Receptor Expression and Signaling
Beteiligte:
Kashyap, Mohit;
Thornton, Angela M.;
Norton, Sarah Kennedy;
Barnstein, Brian;
Macey, Matthew;
Brenzovich, Jennifer;
Shevach, Ethan;
Leonard, Warren J.;
Ryan, John J.
Erschienen:
The American Association of Immunologists, 2008
Erschienen in:
The Journal of Immunology, 180 (2008) 4, Seite 2039-2043
Sprache:
Englisch
DOI:
10.4049/jimmunol.180.4.2039
ISSN:
0022-1767;
1550-6606
Entstehung:
Anmerkungen:
Beschreibung:
Abstract Mast cell activation is associated with atopic and inflammatory diseases, but the natural controls of mast cell homeostasis are poorly understood. We hypothesized that CD4+CD25+ regulatory T cells (Treg) could function in mast cell homeostasis. In this study, we demonstrate that mast cells can recruit both Treg and conventional CD4+ T cells (Tconv). Furthermore, Treg, but not Tconv, suppress mast cell FcεRI expression. Despite the known inhibitory functions of IL-10 and TGFβ1, FcεRI suppression was independent of IL-10 and TGF-β1 and required cell contact. Surprisingly, coculture with either Treg or Tconv cells suppressed IgE-mediated leukotriene C4 production but enhanced cytokine production by mast cells. This was accompanied by a selective increase in FcεRI-mediated Stat5 phosphorylation, which is a critical mediator of IgE-mediated cytokine secretion. These data are the first direct demonstration that mast cells can recruit Treg and illustrate that T cell interactions can alter the mast cell response.