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Medientyp:
E-Artikel
Titel:
Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation
Beteiligte:
Stevens, Kathryn K.;
McQuarrie, Emily P.;
Sands, William;
Hillyard, Dianne Z.;
Patel, Rajan K.;
Mark, Patrick B.;
Jardine, Alan G.
Erschienen:
Hindawi Limited, 2011
Erschienen in:International Journal of Nephrology
Sprache:
Englisch
DOI:
10.4061/2011/297070
ISSN:
2090-214X;
2090-2158
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>Elevated FGF-23 is a predictor of mortality and is associated with LVH in CKD. It may be a biomarker or a direct toxin. We assessed the relationship between FGF-23 and LVH in CKD using CMRI. In vitro we studied the effect of phosphate, FGF-23, and Klotho on E-selectin and VCAM production in HUVECs. FGF-23 concentration correlates negatively with eGFR and positively with LVMI. FGF-23 was an independent predictor of LVH in CKD. E-selectin and VCAM production was elevated in HUVECs cultured in high phosphate with FGF-23 or Klotho. This effect was attenuated in cells exposed to both FGF-23 and Klotho. FGF-23 is an independent predictor of LVH as measured by CMRI. We show preliminary data which supports that FGF-23 is toxic resulting in activation of the vascular endothelium. We do not prove causality with elevated FGF-23 and LVH. Further research should ascertain if lowering levels of FGF-23 translates to improved clinical outcomes.</jats:p>