Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

Medientyp: E-Artikel

Titel: Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

Beteiligte: Eyre, David W; Lumley, Sheila F; O'Donnell, Denise; Campbell, Mark; Sims, Elizabeth; Lawson, Elaine; Warren, Fiona; James, Tim; Cox, Stuart; Howarth, Alison; Doherty, George; Hatch, Stephanie B; Kavanagh, James; Chau, Kevin K; Fowler, Philip W; Swann, Jeremy; Volk, Denis; Yang-Turner, Fan; Stoesser, Nicole; Matthews, Philippa C; Dudareva, Maria; Davies, Timothy; Shaw, Robert H; Peto, Leon; [...]

Erschienen: eLife Sciences Publications, Ltd, 2020

Sprache: Englisch

DOI: 10.7554/elife.60675

ISSN: 2050-084X

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Beschreibung: We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45–6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99–3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07–2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28–0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25–2.21]) and Asian (1.51 [1.28–1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34–3.15]).

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