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Ferris, Mark; Ferris, Rebecca; Workman, Chris; O'Connor, Eoin; Enoch, David A; Goldesgeyme, Emma; Quinnell, Natalie; Patel, Parth; Wright, Jo; Martell, Geraldine; Moody, Christine; Shaw, Ashley; Illingworth, Christopher JR; Matheson, Nicholas J; Weekes, Michael P

Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers

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  • Medientyp: E-Artikel
  • Titel: Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
  • Beteiligte: Ferris, Mark; Ferris, Rebecca; Workman, Chris; O'Connor, Eoin; Enoch, David A; Goldesgeyme, Emma; Quinnell, Natalie; Patel, Parth; Wright, Jo; Martell, Geraldine; Moody, Christine; Shaw, Ashley; Illingworth, Christopher JR; Matheson, Nicholas J; Weekes, Michael P
  • Erschienen: eLife Sciences Publications, Ltd, 2021
  • Erschienen in: eLife
  • Sprache: Englisch
  • DOI: 10.7554/elife.71131
  • ISSN: 2050-084X
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec id="abs1"><jats:title>Background:</jats:title><jats:p>Respiratory protective equipment recommended in the UK for healthcare workers (HCWs) caring for patients with COVID-19 comprises a fluid-resistant surgical mask (FRSM), except in the context of aerosol generating procedures (AGPs). We previously demonstrated frequent pauci- and asymptomatic severe acute respiratory syndrome coronavirus 2 infection HCWs during the first wave of the COVID-19 pandemic in the UK, using a comprehensive PCR-based HCW screening programme (Rivett et al., 2020; Jones et al., 2020).</jats:p></jats:sec><jats:sec id="abs2"><jats:title>Methods:</jats:title><jats:p>Here, we use observational data and mathematical modelling to analyse infection rates amongst HCWs working on ‘red’ (coronavirus disease 2019, COVID-19) and ‘green’ (non-COVID-19) wards during the second wave of the pandemic, before and after the substitution of filtering face piece 3 (FFP3) respirators for FRSMs.</jats:p></jats:sec><jats:sec id="abs3"><jats:title>Results:</jats:title><jats:p>Whilst using FRSMs, HCWs working on red wards faced an approximately 31-fold (and at least fivefold) increased risk of direct, ward-based infection. Conversely, after changing to FFP3 respirators, this risk was significantly reduced (52–100% protection).</jats:p></jats:sec><jats:sec id="abs4"><jats:title>Conclusions:</jats:title><jats:p>FFP3 respirators may therefore provide more effective protection than FRSMs for HCWs caring for patients with COVID-19, whether or not AGPs are undertaken.</jats:p></jats:sec><jats:sec id="abs5"><jats:title>Funding:</jats:title><jats:p>Wellcome Trust, Medical Research Council, Addenbrooke’s Charitable Trust, NIHR Cambridge Biomedical Research Centre, NHS Blood and Transfusion, UKRI.</jats:p></jats:sec>
  • Zugangsstatus: Freier Zugang