• Medientyp: E-Artikel
  • Titel: Drep-2 is a novel synaptic protein important for learning and memory
  • Beteiligte: Andlauer, Till F M; Scholz-Kornehl, Sabrina; Tian, Rui; Kirchner, Marieluise; Babikir, Husam A; Depner, Harald; Loll, Bernhard; Quentin, Christine; Gupta, Varun K; Holt, Matthew G; Dipt, Shubham; Cressy, Michael; Wahl, Markus C; Fiala, André; Selbach, Matthias; Schwärzel, Martin; Sigrist, Stephan J
  • Erschienen: eLife Sciences Publications, Ltd, 2014
  • Erschienen in: eLife, 3 (2014)
  • Sprache: Englisch
  • DOI: 10.7554/elife.03895
  • ISSN: 2050-084X
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input synapses. It was required within Kenyon cells for normal olfactory short- and intermediate-term memory. Drep-2 colocalized with metabotropic glutamate receptors (mGluRs). Chronic pharmacological stimulation of mGluRs compensated for drep-2 learning deficits, and drep-2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in effective mGluR signaling. In fact, Drosophila fragile X protein mutants, shown to benefit from attenuation of mGluR signaling, profited from the elimination of drep-2. Thus, Drep-2 is a novel regulatory synaptic factor, probably intersecting with metabotropic signaling and translational regulation.
  • Zugangsstatus: Freier Zugang