Dulek, Daniel E.;
Williams, John V.;
Creech, C. Buddy;
Schulert, Alynna K.;
Frangoul, Haydar A.;
Domm, Jennifer;
Denison, Mark R.;
Chappell, James D.
Use of Intravenous Zanamivir after Development of Oseltamivir Resistance in a Critically Ill Immunosuppressed Child Infected with 2009 Pandemic Influenza A (H1N1) Virus
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Medientyp:
E-Artikel
Titel:
Use of Intravenous Zanamivir after Development of Oseltamivir Resistance in a Critically Ill Immunosuppressed Child Infected with 2009 Pandemic Influenza A (H1N1) Virus
Beteiligte:
Dulek, Daniel E.;
Williams, John V.;
Creech, C. Buddy;
Schulert, Alynna K.;
Frangoul, Haydar A.;
Domm, Jennifer;
Denison, Mark R.;
Chappell, James D.
Erschienen:
University of Chicago Press, 2010
Erschienen in:
Clinical Infectious Diseases, 50 (2010) 11, Seite 1493-1496
Beschreibung:
Immunosuppressed patients receiving oseltamivir for 2009 novel H1N1 influenza A infection may develop drug resistance, leading to treatment failure. Intravenous zanamivir was administered on a compassionate-use basis to a profoundly immunosuppressed pediatric patient with severe oseltamivir-resistant novel H1N1 pneumonia. The regimen was well tolerated and was associated with a decrease in viral burden.