Yujiri, Toshiaki;
Ware, Margaret;
Widmann, Christian;
Oyer, Ryan;
Russell, David;
Chan, Edward;
Zaitsu, Yuzuru;
Clarke, Penny;
Tyler, Kenneth;
Oka, Yoshitomo;
Fanger, Gary R.;
Henson, Peter;
Johnson, Gary L.
MEK Kinase 1 Gene Disruption Alters Cell Migration and c-Jun NH2-Terminal Kinase Regulation but Does Not Cause a Measurable Defect in NF-κ B Activation
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Medientyp:
E-Artikel
Titel:
MEK Kinase 1 Gene Disruption Alters Cell Migration and c-Jun NH2-Terminal Kinase Regulation but Does Not Cause a Measurable Defect in NF-κ B Activation
Beteiligte:
Yujiri, Toshiaki;
Ware, Margaret;
Widmann, Christian;
Oyer, Ryan;
Russell, David;
Chan, Edward;
Zaitsu, Yuzuru;
Clarke, Penny;
Tyler, Kenneth;
Oka, Yoshitomo;
Fanger, Gary R.;
Henson, Peter;
Johnson, Gary L.
Erschienen:
National Academy of Sciences of the United States of America, 2000
Erschienen in:Proceedings of the National Academy of Sciences of the United States of America
Beschreibung:
<p>MEK kinase 1 (MEKK1) is a 196-kDa mitogen-activated protein kinase (MAPK) kinase kinase that, in addition to regulating the c-Jun NH<sub>2</sub>-terminal kinase (JNK) pathway, is involved in the control of cell motility. MEKK1R-/- mice are defective in eyelid closure, a TGFα -directed process involving the migration of epithelial cells. MEKK1 expression in epithelial cells stimulates lamellipodia formation, a process required for cell movement. In addition, mouse embryo fibroblasts derived from MEKK1<sup>-/-</sup>mice are inhibited in their migration relative to MEKK1<sup>+/+</sup>fibroblasts. MEKK1 is required for JNK but not NF-κ B activation in response to virus infection, microtubule disruption, and stimulation of embryonic stem cells with lysophosphatidic acid. MEKK1 is not required for TNFα or IL-1 regulation of JNK or NF-κ B activation in macrophages or fibroblasts. Thus, MEKK1 senses microtubule integrity, contributes to the regulation of fibroblast and epithelial cell migration, and is required for activation of JNK but not NF-κ B in response to selected stress stimuli.</p>