Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Identification of a Plant Serine-Arginine-Rich Protein Similar to the Mammalian Splicing Factor SF2/ASF
Beteiligte:
Lazar, Gabor;
Schaal, Thomas;
Maniatis, Tom;
Goodman, Howard M.
Erschienen:
National Academy of Sciences of the United States of America, 1995
Erschienen in:
Proceedings of the National Academy of Sciences of the United States of America, 92 (1995) 17, Seite 7672-7676
Sprache:
Englisch
ISSN:
0027-8424
Entstehung:
Anmerkungen:
Beschreibung:
<p>We show that the higher plant Arabidopsis thaliana has a serine-arginine-rich (SR) protein family whose members contain a phosphoepitope shared by the animal SR family of splicing factors. In addition, we report the cloning and characterization of a cDNA encoding a higher-plant SR protein from Arabidopsis, SR1, which has striking sequence and structural homology to the human splicing factor SF2/ASF. Similar to SF2/ASF, the plant SR1 protein promotes splice site switching in mammalian nuclear extracts. A novel feature of the Arabidopsis SR protein is a C-terminal domain containing a high concentration of proline, serine, and lysine residues (PSK domain), a composition reminiscent of histones. This domain includes a putative phosphorylation site for the mitotic kinase cyclin/p34<sup>cdc2</sup>.</p>