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Medientyp:
E-Artikel
Titel:
Chlorpropamide-Alcohol Flushing: A Dominantly Inherited Trait Associated With Diabetes
Beteiligte:
Leslie, R. D. G.;
Pyke, D. A.
Erschienen:
British Medical Association, 1978
Erschienen in:The British Medical Journal
Sprache:
Englisch
ISSN:
0007-1447
Entstehung:
Anmerkungen:
Beschreibung:
<p>A simple test was devised to identify people susceptible to chlorpropamide-alcohol flushing (CPAF). Subjects were given a placebo tablet, followed by sherry 12 and 36 hours later. They then received a chlorpropamide tablet and sherry again after 12 and 36 hours. This single-dose challenge test was given to non-insulin-dependent diabetics, insulin-dependent diabetics, and normal subjects. CPAF was common in the non-insulin-dependent diabetics but rare in the other groups. When the test was used in identical twins and families of affected subjects CPAF appeared to be a dominantly inherited trait. We conclude that facial flushing after alcohol in people taking chlorpropamide is related to non-insulin-dependent diabetes, especially when there is a strong family history of diabetes, but not to insulin-dependent diabetes. It is a dominantly inherited trait.</p>