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Holt, Kathryn E.; Wertheim, Heiman; Zadoks, Ruth N.; Baker, Stephen; Whitehouse, Chris A.; Dance, David; Jenney, Adam; Connor, Thomas R.; Hsu, Li Yang; Severin, Juliëtte; Brisse, Sylvain; Cao, Hanwei; Wilksch, Jonathan; Gorrie, Claire; Schultz, Mark B.; Edwards, David J.; Van Nguyen, Kinh; Nguyen, Trung Vu; Dao, Trinh Tuyet; Mensink, Martijn; Le Minh, Vien; Nhu, Nguyen Thi Khanh; Schultsz, Constance; Kuntaman, Kuntaman; [...]

Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance inKlebsiella pneumoniae,an urgent threat to public health

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  • Medientyp: E-Artikel
  • Titel: Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance inKlebsiella pneumoniae,an urgent threat to public health
  • Beteiligte: Holt, Kathryn E.; Wertheim, Heiman; Zadoks, Ruth N.; Baker, Stephen; Whitehouse, Chris A.; Dance, David; Jenney, Adam; Connor, Thomas R.; Hsu, Li Yang; Severin, Juliëtte; Brisse, Sylvain; Cao, Hanwei; Wilksch, Jonathan; Gorrie, Claire; Schultz, Mark B.; Edwards, David J.; Van Nguyen, Kinh; Nguyen, Trung Vu; Dao, Trinh Tuyet; Mensink, Martijn; Le Minh, Vien; Nhu, Nguyen Thi Khanh; Schultsz, Constance; Kuntaman, Kuntaman; [...]
  • Erschienen: National Academy of Sciences, 2015
  • Erschienen in: Proceedings of the National Academy of Sciences of the United States of America
  • Sprache: Englisch
  • ISSN: 0027-8424; 1091-6490
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <p> <italic>Klebsiella pneumoniae</italic>is now recognized as an urgent threat to human health because of the emergence of multidrug-resistant strains associated with hospital outbreaks and hypervirulent strains associated with severe community-acquired infections.<italic>K. pneumoniae</italic>is ubiquitous in the environment and can colonize and infect both plants and animals. However, little is known about the population structure of<italic>K. pneumoniae,</italic>so it is difficult to recognize or understand the emergence of clinically important clones within this highly genetically diverse species. Here we present a detailed genomic framework for<italic>K. pneumoniae</italic>based on whole-genome sequencing of more than 300 human and animal isolates spanning four continents. Our data provide genomewide support for the splitting of<italic>K. pneumoniae</italic>into three distinct species, KpI (<italic>K. pneumoniae</italic>), KpII (<italic>K. quasipneumoniae</italic>), and KpIII (<italic>K. variicola</italic>). Further, for<italic>K. pneumoniae</italic>(KpI), the entity most frequently associated with human infection, we show the existence of &gt;150 deeply branching lineages including numerous multidrug-resistant or hypervirulent clones. We show<italic>K. pneumoniae</italic>has a large accessory genome approaching 30,000 protein-coding genes, including a number of virulence functions that are significantly associated with invasive community-acquired disease in humans. In our dataset, antimicrobial resistance genes were common among human carriage isolates and hospital-acquired infections, which generally lacked the genes associated with invasive disease. The convergence of virulence and resistance genes potentially could lead to the emergence of untreatable invasive<italic>K. pneumoniae</italic>infections; our data provide the whole-genome framework against which to track the emergence of such threats.</p>
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