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Graham, Simon P.; Pellé, Roger; Honda, Yoshikazu; Mwangi, Duncan M.; Tonukari, Nyerhovwo J.; Yamage, Mat; Glew, E. Jane; de Villiers, Etienne P.; Shah, Trushar; Bishop, Richard; Abuya, Evelyne; Awino, Elias; Gachanja, James; Luyai, Anthony E.; Mbwika, Ferdinand; Muthiani, Anthony M.; Ndegwa, David M.; Njahira, Moses; Nyanjui, John K.; Onono, Fredrick O.; Osaso, Julius; Saya, Rosemary M.; Wildmann, Claude; Fraser, Claire M.; [...]

Theileria parva Candidate Vaccine Antigens Recognized by Immune Bovine Cytotoxic T Lymphocytes

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  • Medientyp: E-Artikel
  • Titel: Theileria parva Candidate Vaccine Antigens Recognized by Immune Bovine Cytotoxic T Lymphocytes
  • Beteiligte: Graham, Simon P.; Pellé, Roger; Honda, Yoshikazu; Mwangi, Duncan M.; Tonukari, Nyerhovwo J.; Yamage, Mat; Glew, E. Jane; de Villiers, Etienne P.; Shah, Trushar; Bishop, Richard; Abuya, Evelyne; Awino, Elias; Gachanja, James; Luyai, Anthony E.; Mbwika, Ferdinand; Muthiani, Anthony M.; Ndegwa, David M.; Njahira, Moses; Nyanjui, John K.; Onono, Fredrick O.; Osaso, Julius; Saya, Rosemary M.; Wildmann, Claude; Fraser, Claire M.; [...]
  • Erschienen: National Academy of Sciences, 2006
  • Erschienen in: Proceedings of the National Academy of Sciences of the United States of America
  • Sprache: Englisch
  • ISSN: 0027-8424
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <p>East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-infected cell-directed CD8⁺ cytotoxic T lymphocytes (CTL) constitute the dominant protective bovine immune response after a single exposure to infection. However, the schizont antigens targeted by T. parva-specific CTL are undefined. Here we show the identification of five candidate vaccine antigens that are the targets of MHC class I-restricted CD8⁺ CTL from immune cattle. CD8⁺ T cell responses to these antigens were boosted in T. parva-immune cattle resolving a challenge infection and, when used to immunize naïve cattle, induced CTL responses that significantly correlated with survival from a lethal parasite challenge. These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites.</p>
  • Zugangsstatus: Freier Zugang