Saag, Michael S.;
Crain, Marilyn J.;
Decker, W. Don;
Campbell-Hill, Sherri;
Robinson, Susan;
Brown, William E.;
Leuther, Michael;
Whitley, Richard J.;
Hahn, Beatrice H.;
Shaw, George M.
High-Level Viremia in Adults and Children Infected with Human Immunodeficiency Virus: Relation to Disease Stage and CD4⁺ Lymphocyte Levels
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Medientyp:
E-Artikel
Titel:
High-Level Viremia in Adults and Children Infected with Human Immunodeficiency Virus: Relation to Disease Stage and CD4⁺ Lymphocyte Levels
Beteiligte:
Saag, Michael S.;
Crain, Marilyn J.;
Decker, W. Don;
Campbell-Hill, Sherri;
Robinson, Susan;
Brown, William E.;
Leuther, Michael;
Whitley, Richard J.;
Hahn, Beatrice H.;
Shaw, George M.
Erschienen:
University of Chicago Press, 1991
Erschienen in:
The Journal of Infectious Diseases, 164 (1991) 1, Seite 72-80
Beschreibung:
Sixty-eight adults and nine children infected with human immunodeficiency virus type 1 (HIV-1) were evaluated consecutively for the presence and amount of cell-free infectious virus in their plasma. Viremia was detected in 18 of 68 adults and in five of nine children; titers ranged from 10 to 100,000,000 TCID/ml plasma. Among the adults, none of 19 asymptomatic patients, 4 of 34 AIDS-related complex patients, and 14 of 15 AIDS patients had cell-free infectious virus in their plasma. None of 35 adult subjects with CD4⁺ lymphocyte counts >400/mm³ were viremic, whereas 3 of 17 with 200-400 CD4⁺ lymphocytes/mm³ and 15 of 16 individuals with <200 CD4⁺ lymphocytes/mm³ were plasma viremic. In contrast to adults, each of five children infected with HIV-1 in utero or during the perinatal period were plasma viremic regardless of their CD4⁺ lymphocyte counts (range, 42-2227/mm³), duration of infection, or clinical stage; however, children infected by HIV-1 at older ages were less frequently plasma viremic. Therapy with zidovudine led to a 10- to 10⁶-fold decline in plasma HIV-1 TCID in all eight subjects studied before and after treatment.