Klein, Robert S.;
Selwyn, Peter A.;
Maude, Diana;
Pollard, Catherine;
Freeman, Katherine;
Schiffman, Gerald
Response to Pneumococcal Vaccine among Asymptomatic Heterosexual Partners of Persons with AIDS and Intravenous Drug Users Infected with Human Immunodeficiency Virus
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Medientyp:
E-Artikel
Titel:
Response to Pneumococcal Vaccine among Asymptomatic Heterosexual Partners of Persons with AIDS and Intravenous Drug Users Infected with Human Immunodeficiency Virus
Beteiligte:
Klein, Robert S.;
Selwyn, Peter A.;
Maude, Diana;
Pollard, Catherine;
Freeman, Katherine;
Schiffman, Gerald
Erschienen:
University of Chicago Press, 1989
Erschienen in:
The Journal of Infectious Diseases, 160 (1989) 5, Seite 826-831
Beschreibung:
Antibody responses to pneumococcal vaccine were studied in asymptomatic heterosexual partners of persons with AIDS and intravenous drug users seropositive for human immu-nodeficiency virus (HIV). Serum antibodies to 12 pneumococcal capsular antigens were measured by radioimunoassay. Eleven intravenous drug users seropositive for HIV, 13 seronegative intravenous drug users, and 10 each seropositive and seronegative sexual partners received 23-valent pneumococcal vaccine. Additional unvaccinated matched seroposi-tives served as controls. Antibody responses were significantly lower among subjects seropositive for HIV (P < .05). Fourteen (88%) of 16 seropositive subjects with baseline type-specific antibodies to one or more pneumococcal antigens <300 ng of antibody nitrogen/ml (ngAbN/ml) demonstrated a rise in one or more of these antibodies to >400 ngAbN/ml. No clinical deterioration or decrease in T4 cells attributable to vaccination was found. Although antibody responses to pneumococcal vaccine among HIV-infected subjects were impaired, most with antibody levels <300 ngAbN/ml developed titers of one or more type-specific antibodies to levels >400 ngAbN/ml without notable adverse effects.