McClain, David J.;
Harrison, Shannon;
Yeager, Curtis L.;
Cruz, John;
Ennis, Francis A.;
Gibbs, Paul;
Wright, Michael S.;
Summers, Peter L.;
Arthur, James D.;
Graham, Jess A.
Immunologic Responses to Vaccinia Vaccines Administered by Different Parenteral Routes
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Medientyp:
E-Artikel
Titel:
Immunologic Responses to Vaccinia Vaccines Administered by Different Parenteral Routes
Beteiligte:
McClain, David J.;
Harrison, Shannon;
Yeager, Curtis L.;
Cruz, John;
Ennis, Francis A.;
Gibbs, Paul;
Wright, Michael S.;
Summers, Peter L.;
Arthur, James D.;
Graham, Jess A.
Erschienen:
University of Chicago Press, 1997
Erschienen in:
The Journal of Infectious Diseases, 175 (1997) 4, Seite 756-763
Beschreibung:
To develop a less reactogenic but equally immunogenic vaccine, this study of 91 human volunteers compared the safety and immunogenic potency of a new, cell culture-derived vaccinia virus vaccine administered intradermally and intramuscularly with the licensed vaccinia vaccine administered by scarification. Cutaneous pox lesions developed in a higher proportion of scarification vaccinees. Scarification and intradermal vaccine recipients who developed cutaneous pox lesions had more local reactions but also achieved significantly higher cell-mediated and neutralizing antibody responses than those who did not develop pox lesions. Although less reactogenic, intradermal or intramuscular administration of vaccinia vaccine without the concomitant development of a cutaneous pox lesion induced lower immune responses.