Purvis, Scott F.;
Katongole-Mbidde, Edward;
Johnson, John L.;
Leonard, Debra G. B.;
Byabazaire, Naome;
Luckey, Carol;
Schick, H. Elizabeth;
Wallis, Robert;
Elmets, Craig A.;
Giam, Chou-Zen
High Incidence of Kaposi's Sarcoma-Associated Herpesvirus and Epstein-Barr Virus in Tumor Lesions and Peripheral Blood Mononuclear Cells from Patients with Kaposi's Sarcoma in Uganda
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Medientyp:
E-Artikel
Titel:
High Incidence of Kaposi's Sarcoma-Associated Herpesvirus and Epstein-Barr Virus in Tumor Lesions and Peripheral Blood Mononuclear Cells from Patients with Kaposi's Sarcoma in Uganda
Beteiligte:
Purvis, Scott F.;
Katongole-Mbidde, Edward;
Johnson, John L.;
Leonard, Debra G. B.;
Byabazaire, Naome;
Luckey, Carol;
Schick, H. Elizabeth;
Wallis, Robert;
Elmets, Craig A.;
Giam, Chou-Zen
Erschienen:
University of Chicago Press, 1997
Erschienen in:
The Journal of Infectious Diseases, 175 (1997) 4, Seite 947-950
Beschreibung:
With the advent of AIDS, Kaposi's sarcoma (KS) has become one of the leading malignancies in sub-Saharan Africa. Recently, DNA sequences from a new human herpesvirus called KS-associated herpesvirus (KSHV) or human herpesvirus type 8 have been found in KS tumor lesions in high frequency. Analyses of tumor lesions from 38 Ugandan KS patients indicated a uniform presence of KSHV in KS tumor lesions as revealed by polymerase chain reaction and Southern hybridization. In contrast, only 31% (11/36) of the normal skin biopsies from the same patient population were positive. The frequency of KSHV DNA detection in peripheral blood mononuclear cells (PBMC) of KS patients was also high (84%, 31/37). Similar analyses revealed the presence of cytomegalovirus (21% in KS lesions) to be discordant with KS development. A large number of KS lesions (87%, 33/38) and KS PBMC (70%, 26/37) were, however, positive for Epstein-Barr virus sequences. In addition, KSHV DNA was not found in the PBMC of Ugandans without KS.