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Perno, Carlo F.; Cozzi-Lepri, Alessandro; Balotta, Claudia; Forbici, Federica; Violin, Michela; Bertoli, Ada; Facchi, Guido; Pezzotti, Patrizio; Cadeo, Gianpiero; Tositti, Giulio; Pasquinucci, Sandro; Pauluzzi, Sergio; Scalzini, Alfredo; Salassa, Bernardino; Vincenti, Antonella; Phillips, Andrew N.; Dianzani, Ferdinando; Appice, Amelia; Angarano, Gioacchino; Monno, Laura; Ippolito, Giuseppe; Moroni, Mauro; Monforte, Antonella d'Arminio

Secondary Mutations in the Protease Region of Human Immunodeficiency Virus and Virologic Failure in Drug-Naive Patients Treated with Protease Inhibitor-Based Therapy

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  • Medientyp: E-Artikel
  • Titel: Secondary Mutations in the Protease Region of Human Immunodeficiency Virus and Virologic Failure in Drug-Naive Patients Treated with Protease Inhibitor-Based Therapy
  • Beteiligte: Perno, Carlo F.; Cozzi-Lepri, Alessandro; Balotta, Claudia; Forbici, Federica; Violin, Michela; Bertoli, Ada; Facchi, Guido; Pezzotti, Patrizio; Cadeo, Gianpiero; Tositti, Giulio; Pasquinucci, Sandro; Pauluzzi, Sergio; Scalzini, Alfredo; Salassa, Bernardino; Vincenti, Antonella; Phillips, Andrew N.; Dianzani, Ferdinando; Appice, Amelia; Angarano, Gioacchino; Monno, Laura; Ippolito, Giuseppe; Moroni, Mauro; Monforte, Antonella d'Arminio
  • Erschienen: University of Chicago Press, 2001
  • Erschienen in: The Journal of Infectious Diseases
  • Sprache: Englisch
  • ISSN: 0022-1899
  • Schlagwörter: Major Article
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <p>The role of mutations in protease (PR) and reverse-transcriptase (RT) of human immunodeficiency virus (HIV) in predicting virologic failure was assessed in 248 antiretroviral-naive HIV-positive patients who began a PR inhibitor-containing antiretroviral regimen. Genotypic testing was performed on plasma samples stored before the start of therapy. Twenty-seven patients (10.9%) had mutations in the RT, 5 (2%) carried primary mutations in the PR, and 131 (52.8%) showed only secondary PR mutations. Virologic failure at week 24 occurred in 62 (25.0%) of 248 patients. There was a statistically significant correlation between virologic failure and the number of PR mutations (P = .04, x2 test). Mutations at codons 10 and 36 of PR (present in 39.3% and 40.0% of patients in whom treatment failed, respectively) were identified by stepwise logistic regression as the strongest predictors of virologic failure (odds ratio, 2.20; 95% confidence interval, 1.30-3.75; P = .004). If confirmed in independent studies, this result may justify the increased use of HIV genotyping in drug-naive patients requiring antiretroviral therapy.</p>
  • Zugangsstatus: Freier Zugang