Identification of Plasmodium falciparum Antigens by Antigenic Analysis of Genomic and Proteomic Data

Medientyp: E-Artikel
Titel: Identification of Plasmodium falciparum Antigens by Antigenic Analysis of Genomic and Proteomic Data
Beteiligte: Doolan, Denise L.; Southwood, Scott; Freilich, Daniel A.; Sidney, John; Graber, Norma L.; Shatney, Lori; Bebris, Lolita; Florens, Laurence; Dobano, Carlota; Witney, Adam A.; Appella, Ettore; Hoffman, Stephen L.; Yates, John R.; Carucci, Daniel J.; Sette, Alessandro
Erschienen: National Academy of Sciences, 2003
Erschienen in: Proceedings of the National Academy of Sciences of the United States of America, 100 (2003) 17, Seite 9952-9957
Sprache: Englisch
ISSN: 0027-8424
Schlagwörter: Biological Sciences
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Beschreibung: <p>The recent explosion in genomic sequencing has made available a wealth of data that can now be analyzed to identify protein antigens, potential targets for vaccine development. Here we present, in the context of Plasmodium falciparum, a strategy that rapidly identifies target antigens from large and complex genomes. Sixteen antigenic proteins recognized by volunteers immunized with radiation-attenuated P. falciparum sporozoites, but not by mock immunized controls, were identified. Several of these were more antigenic than previously identified and well characterized P. falciparum-derived protein antigens. The data suggest that immune responses to Plasmodium are dispersed on a relatively large number of parasite antigens. These studies have implications for our understanding of immunodominance and breadth of responses to complex pathogens.</p>
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