Host-Parasite Relationships of Fasciola hepatica in the White Mouse. IV. Studies on Worm Transfer and the Induction of Acquired Immunity by Worms of Different Ages
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Medientyp:
E-Artikel
Titel:
Host-Parasite Relationships of Fasciola hepatica in the White Mouse. IV. Studies on Worm Transfer and the Induction of Acquired Immunity by Worms of Different Ages
Beteiligte:
Lang, Bruce Z.;
Dronen,, Norman O.
Erschienen:
American Society of Parasitologists, 1972
Erschienen in:
The Journal of Parasitology, 58 (1972) 1, Seite 84-87
Sprache:
Englisch
ISSN:
0022-3395;
1937-2345
Entstehung:
Anmerkungen:
Beschreibung:
Eight- and 16-day-old worms were transferred to normal recipient mice via peritoneal injection, contacted the liver 72 hr after transfer, and migrated into the common bile duct when total worm age was 32 days. Eight-day-old transferred worms were present in the liver parenchyma of recipient mice for 21 to 22 days, while 16-day-old transferred worms were in the liver parenchyma for 13 to 14 days. Transferred worms (8- and 16-day-old) were utilized as immunizing infections in 2 groups of normal recipient mice to control the duration of liver migration. When transferred worms had a total age of 40 days, immunized mice were given a challenge infection of 2 metacercariae per mouse. At 25 days after challenge, these mice were killed and worms were recovered. Immunization with 8- and 16-day-old worms produced a significant reduction in challenge worm burden when compared to natural immunity controls. Apparently, young flukes are capable of inducing acquired immunity during the entire liver migration period.