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Abumayyaleh, Mohammad S. A.
[Author];
Nuñez-Gil, Iván J.
[Author];
El-Battrawy, Ibrahim
[Author];
Estrada, Vicente
[Author];
Becerra-Muñoz, Víctor Manuel
[Author];
Uribarri, Aitor
[Author];
Fernández-Rozas, Inmaculada
[Author];
Feltes, Gisela
[Author];
Arroyo-Espliguero, Ramón
[Author];
Trabattoni, Daniela
[Author];
López Pais, Javier
[Author];
Pepe, Martino
[Author];
Romero, Rodolfo
[Author];
Ortega-Armas, María Elizabeth
[Author];
Bianco, Matteo
[Author];
Astrua, Thamar Capel
[Author];
D'Ascenzo, Fabrizio
[Author];
Fabregat-Andres, Oscar
[Author];
Ballester, Andrea
[Author];
Marín, Francisco
[Author];
Buonsenso, Danilo
[Author];
Sanchez-Gimenez, Raul
[Author];
Weiß, Christel
[Author];
Fernandez Perez, Cristina
[Author];
[...]
Sepsis of patients infected by SARS-CoV-2
: real-world experience from the international HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
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- Media type: E-Article
- Title: Sepsis of patients infected by SARS-CoV-2 : real-world experience from the international HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
- Contributor: Abumayyaleh, Mohammad S. A. [VerfasserIn]; Nuñez-Gil, Iván J. [VerfasserIn]; El-Battrawy, Ibrahim [VerfasserIn]; Estrada, Vicente [VerfasserIn]; Becerra-Muñoz, Víctor Manuel [VerfasserIn]; Uribarri, Aitor [VerfasserIn]; Fernández-Rozas, Inmaculada [VerfasserIn]; Feltes, Gisela [VerfasserIn]; Arroyo-Espliguero, Ramón [VerfasserIn]; Trabattoni, Daniela [VerfasserIn]; López Pais, Javier [VerfasserIn]; Pepe, Martino [VerfasserIn]; Romero, Rodolfo [VerfasserIn]; Ortega-Armas, María Elizabeth [VerfasserIn]; Bianco, Matteo [VerfasserIn]; Astrua, Thamar Capel [VerfasserIn]; D'Ascenzo, Fabrizio [VerfasserIn]; Fabregat-Andres, Oscar [VerfasserIn]; Ballester, Andrea [VerfasserIn]; Marín, Francisco [VerfasserIn]; Buonsenso, Danilo [VerfasserIn]; Sanchez-Gimenez, Raul [VerfasserIn]; Weiß, Christel [VerfasserIn]; Fernandez Perez, Cristina [VerfasserIn]; Fernández-Ortiz, Antonio [VerfasserIn]; Macaya, Carlos [VerfasserIn]; Akın, Ibrahim [VerfasserIn]
- imprint: 14 October 2021
- Published in: Frontiers in medicine ; 8(2021) vom: 14. Okt., Artikel-ID 728102, Seite 1-10
- Language: English
- DOI: 10.3389/fmed.2021.728102
- ISSN: 2296-858X
- Identifier:
- Origination:
- Footnote:
- Description: Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19.Methods: We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus.Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (>22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO2) <92%, blood pressure (BP) (systolic BP <90 mmHg and diastolic BP <60 mmHg), Glasgow Coma Scale (GCS) <15, elevated procalcitonin (PCT), elevated troponin I (TnI), and elevated creatinine >1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1-11.8%); intermediate-risk group (24.8-53.8%); and high-risk-group (58.3-100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO2, decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis.Conclusions: The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate.
- Access State: Open Access