Sepsis of patients infected by SARS-CoV-2: real-world experience from the international HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score

Medientyp: E-Artikel

Titel: Sepsis of patients infected by SARS-CoV-2 : real-world experience from the international HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score

Beteiligte: Abumayyaleh, Mohammad S. A. [Verfasser:in]; Nuñez-Gil, Iván J. [Verfasser:in]; El-Battrawy, Ibrahim [Verfasser:in]; Estrada, Vicente [Verfasser:in]; Becerra-Muñoz, Víctor Manuel [Verfasser:in]; Uribarri, Aitor [Verfasser:in]; Fernández-Rozas, Inmaculada [Verfasser:in]; Feltes, Gisela [Verfasser:in]; Arroyo-Espliguero, Ramón [Verfasser:in]; Trabattoni, Daniela [Verfasser:in]; López Pais, Javier [Verfasser:in]; Pepe, Martino [Verfasser:in]; Romero, Rodolfo [Verfasser:in]; Ortega-Armas, María Elizabeth [Verfasser:in]; Bianco, Matteo [Verfasser:in]; Astrua, Thamar Capel [Verfasser:in]; D'Ascenzo, Fabrizio [Verfasser:in]; Fabregat-Andres, Oscar [Verfasser:in]; Ballester, Andrea [Verfasser:in]; Marín, Francisco [Verfasser:in]; Buonsenso, Danilo [Verfasser:in]; Sanchez-Gimenez, Raul [Verfasser:in]; Weiß, Christel [Verfasser:in]; Fernandez Perez, Cristina [Verfasser:in]; Fernández-Ortiz, Antonio [Verfasser:in]; Macaya, Carlos [Verfasser:in]; Akın, Ibrahim [Verfasser:in]

Erschienen: 14 October 2021

Sprache: Englisch

DOI: 10.3389/fmed.2021.728102

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Beschreibung: Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19.Methods: We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus.Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (>22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO2) <92%, blood pressure (BP) (systolic BP <90 mmHg and diastolic BP <60 mmHg), Glasgow Coma Scale (GCS) <15, elevated procalcitonin (PCT), elevated troponin I (TnI), and elevated creatinine >1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1-11.8%); intermediate-risk group (24.8-53.8%); and high-risk-group (58.3-100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO2, decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis.Conclusions: The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate.

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