Description:
During the cell cycle progression, synthesis of new histones is important to pack newly synthesized DNA and to maintain proper chromatin structure. Unlike normal mRNAs, mRNAs from replication-dependent histone genes that are expressed in the S phase of the cell cycle are not polyadenylated at the 3'end. They contain a conserved stem-loop sequence which forms a stem-loop structure which is required for the proper processing of the 3'end, translation and degradation of histone mRNAs. However, a number of studies show that replication-dependent histone genes can produce mRNAs which have a poly...