• Medientyp: E-Book; Hochschulschrift
  • Titel: Role of histone metabolism and chromatin structure in DNA repair
  • Beteiligte: Kari, Vijaya Lakshmi [Verfasser:in]; Johnsen, Steven [Sonstige Person, Familie und Körperschaft]; Reichardt, Holger [Sonstige Person, Familie und Körperschaft]; Kehlenbach, Ralph [Sonstige Person, Familie und Körperschaft]
  • Erschienen: 2013
  • Umfang: Online-Ressource (PDF-Datei: 3,2 MB)
  • Sprache: Englisch
  • Identifikator:
  • Schlagwörter: Hochschulschrift
  • Entstehung:
  • Hochschulschrift: Göttingen, Univ., Diss., 2013
  • Anmerkungen:
  • Beschreibung: During the cell cycle progression, synthesis of new histones is important to pack newly synthesized DNA and to maintain proper chromatin structure. Unlike normal mRNAs, mRNAs from replication-dependent histone genes that are expressed in the S phase of the cell cycle are not polyadenylated at the 3'end. They contain a conserved stem-loop sequence which forms a stem-loop structure which is required for the proper processing of the 3'end, translation and degradation of histone mRNAs. However, a number of studies show that replication-dependent histone genes can produce mRNAs which have a poly...
  • Zugangsstatus: Freier Zugang