Description:
Myelin is a unique lipid-enriched membrane, produced by oligodendrocytes in the central nervous system, that is enwrapped around axons in the multilayered fashion to ensure a swift saltatory conduction of the neuronal impulses. Myelin has a unique composition. It is enriched in the cholesterol, sphingomyelin and myelin lipids possess high number of long-chain fatty acids in their structure. Previous results have shown that myelin basic protein (MBP) acts as a diffusion barrier within myelin sheath, preventing the majority of the proteins to enter the sheath region. Therefore, myelin sheaths...