• Medientyp: E-Book; Hochschulschrift
  • Titel: Lipid organisation and dynamics in the myelin membrane sheets
  • Beteiligte: Steshenko, Olena [VerfasserIn]; Simons, Mikael [Betreuer]; Rizzoli, Silvio [Gutachter]; Enderlein, Jörg [Gutachter]
  • Erschienen: 2013
  • Umfang: Online-Ressource (PDF-Datei: 3,8 MB)
  • Sprache: Englisch
  • Identifikator:
  • Schlagwörter: Hochschulschrift
  • Entstehung:
  • Hochschulschrift: Göttingen, Univ., Diss., 2013
  • Anmerkungen:
  • Beschreibung: Myelin is a unique lipid-enriched membrane, produced by oligodendrocytes in the central nervous system, that is enwrapped around axons in the multilayered fashion to ensure a swift saltatory conduction of the neuronal impulses. Myelin has a unique composition. It is enriched in the cholesterol, sphingomyelin and myelin lipids possess high number of long-chain fatty acids in their structure. Previous results have shown that myelin basic protein (MBP) acts as a diffusion barrier within myelin sheath, preventing the majority of the proteins to enter the sheath region. Therefore, myelin sheaths...
  • Zugangsstatus: Freier Zugang