Description:
CHARGE syndrome is a complex malformation syndrome affecting several organ systems like the central nervous system, ear, eye and heart. Heterozygous loss of function mutations in CHD7, a conserved chromatin remodelling enzyme, are responsible to cause about two-thirds of CHARGE syndrome cases. CHD7 is present in large multi-subunit complexes regulating gene transcription in a time and cell type specific manner. In this work, it was shown by co-immunoprecipitation and Duolink proximity ligation assay that CHD7 interacts with the WAR complex members WDR5, ASH2L and RBBP5. Additional direct ye...