> Details

Jonczyk, Rebecca [Author]; Stanislawski, Nils [Author]; Seiler, Lisa K. [Author]; Blume, Holger [Author]; Heiden, Stefanie [Author]; Lucas, Henning [Author]; Sarikouch, Samir [Author]; Pott, Philipp-Cornelius [Author]; Stiesch, Meike [Author]; Hauß, Corinna [Author]; Saletti, Giulietta [Author]; González-Hernández, Mariana [Author]; Kaiser, Franziska Karola [Author]; Rimmelzwaan, Guus [Author]; Osterhaus, Albert [Author]; Blume, Cornelia [Author]

Combined Prospective Seroconversion and PCR Data of Selected Cohorts Indicate a High Rate of Subclinical SARS-CoV-2 Infections—an Open Observational Study in Lower Saxony, Germany - [published Version]

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article; Text
  • Title: Combined Prospective Seroconversion and PCR Data of Selected Cohorts Indicate a High Rate of Subclinical SARS-CoV-2 Infections—an Open Observational Study in Lower Saxony, Germany
  • Contributor: Jonczyk, Rebecca [Author]; Stanislawski, Nils [Author]; Seiler, Lisa K. [Author]; Blume, Holger [Author]; Heiden, Stefanie [Author]; Lucas, Henning [Author]; Sarikouch, Samir [Author]; Pott, Philipp-Cornelius [Author]; Stiesch, Meike [Author]; Hauß, Corinna [Author]; Saletti, Giulietta [Author]; González-Hernández, Mariana [Author]; Kaiser, Franziska Karola [Author]; Rimmelzwaan, Guus [Author]; Osterhaus, Albert [Author]; Blume, Cornelia [Author]
  • imprint: Birmingham, Ala. : ASM, 2022
  • Published in: Microbiology spectrum 10 (2022), Nr. 1 ; Microbiology spectrum
  • Issue: published Version
  • Language: English
  • DOI: https://doi.org/10.15488/12234; https://doi.org/10.1128/spectrum.01512-21
  • Keywords: COVID-19 ; working groups ; PCR ; antibody screening tests ; neutralizing antibodies ; subclinical cases ; SARS-CoV-2 antibody screening
  • Origination:
  • Footnote: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Description: Despite lockdown measures, intense symptom-based PCR, and antigen testing, the SARS-CoV-2 pandemic spread further. In this open observational study conducted in Lower Saxony, Germany, voluntary SARS-CoV-2 PCR tests were performed from April 2020 until June 2021, supported by serum antibody testing to prove whether PCR testing in subjects with none or few symptoms of COVID-19 is a suitable tool to manage the pandemic. In different mobile stations, 4,817 subjects from three different working fields participated in the PCR testing. Serum antibody screening using the SARS-CoV-2 ViraChip IgG (Viramed, Germany) and the Elecsys Anti-SARS-CoV-2 assay (Roche, Germany) was performed alongside virus neutralization testing. Subjects were questioned regarding comorbidities and COVID-19 symptoms. Fifty-one subjects with acute SARS-CoV-2 infection were detected of which 31 subjects did not show any symptoms possibly characteristic for COVID-19. An additional 37 subjects reported a previous SARS-CoV-2 infection (total prevalence 1.82%). Seroconversion was discovered in 58 subjects with known SARS-CoV-2 infection and in 58 subjects that never had a positive PCR test. The latter had a significantly lower Charlson Comorbidity Index, and one third of them were asymptomatic. In 50% of all seroconverted subjects, neutralizing serum antibodies (NAbs) were detectable in parallel to N/S1 (n = 16) or N/S1/S2 antigen specific antibodies (n = 40) against SARS-CoV-2. NAb titers decreased within 100 days after PCR-confirmed SARS-CoV-2 acute infection by at least 2.5-fold. A relatively high rate of subclinical SARS-CoV-2 infections may contribute to the spread of SARS-CoV-2, suggesting that in addition to other intervention strategies, systematic screening of asymptomatic persons by PCR testing may significantly enable better pandemic control.
  • Access State: Open Access
  • Rights information: Attribution (CC BY)