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Berger, John T.; Villalobos, Michele E.; Clark, Amy E.; Holubkov, Richard; Pollack, Murray M.; Berg, Robert A.; Carcillo, Joseph A.; Dalton, Heidi; Harrison, Rick; Meert, Kathleen L.; Newth, Christopher J. L.; Shanley, Thomas P.; Wessel, David L.; Anand, Kanwaljeet J. S.; Zimmerman, Jerry J.; Sanders, Ronald C.; Liu, Teresa; Burr, Jeri S.; Willson, Douglas F.; Doctor, Allan; Dean, J. Michael; Jenkins, Tammara L.; Nicholson, Carol E.

Cognitive Development One Year After Infantile Critical Pertussis*

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  • Media type: E-Article
  • Title: Cognitive Development One Year After Infantile Critical Pertussis*
  • Contributor: Berger, John T.; Villalobos, Michele E.; Clark, Amy E.; Holubkov, Richard; Pollack, Murray M.; Berg, Robert A.; Carcillo, Joseph A.; Dalton, Heidi; Harrison, Rick; Meert, Kathleen L.; Newth, Christopher J. L.; Shanley, Thomas P.; Wessel, David L.; Anand, Kanwaljeet J. S.; Zimmerman, Jerry J.; Sanders, Ronald C.; Liu, Teresa; Burr, Jeri S.; Willson, Douglas F.; Doctor, Allan; Dean, J. Michael; Jenkins, Tammara L.; Nicholson, Carol E.
  • Published: Ovid Technologies (Wolters Kluwer Health), 2018
  • Published in: Pediatric Critical Care Medicine, 19 (2018) 2, Seite 89-97
  • Language: English
  • DOI: 10.1097/pcc.0000000000001367
  • ISSN: 1529-7535
  • Keywords: Critical Care and Intensive Care Medicine ; Pediatrics, Perinatology and Child Health
  • Origination:
  • Footnote:
  • Description: <jats:sec> <jats:title>Objectives:</jats:title> <jats:p>Pertussis can cause life-threatening illness in infants. Data regarding neurodevelopment after pertussis remain scant. The aim of this study was to assess cognitive development of infants with critical pertussis 1 year after PICU discharge.</jats:p> </jats:sec> <jats:sec> <jats:title>Design:</jats:title> <jats:p>Prospective cohort study.</jats:p> </jats:sec> <jats:sec> <jats:title>Setting:</jats:title> <jats:p>Eight hospitals comprising the <jats:italic toggle="yes">Eunice Kennedy Shriver</jats:italic> National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network and 18 additional sites across the United States.</jats:p> </jats:sec> <jats:sec> <jats:title>Patients:</jats:title> <jats:p>Eligible patients had laboratory confirmation of pertussis infection, were less than 1 year old, and were admitted to the PICU for at least 24 hours.</jats:p> </jats:sec> <jats:sec> <jats:title>Interventions:</jats:title> <jats:p>The Mullen Scales of Early Learning was administered at a 1-year follow-up visit. Functional status was determined by examination and parental interview.</jats:p> </jats:sec> <jats:sec> <jats:title>Measurements and Main Results:</jats:title> <jats:p>Of 196 eligible patients, 111 (57%) completed the Mullen Scales of Early Learning. The mean scores for visual reception, receptive language, and expressive language domains were significantly lower than the norms (<jats:italic toggle="yes">p</jats:italic> &lt; 0.001), but not fine and gross motor domains. Forty-one patients (37%) had abnormal scores in at least one domain and 10 (9%) had an Early Learning Composite score 2 or more <jats:sc>sd</jats:sc>s below the population norms. Older age (<jats:italic toggle="yes">p</jats:italic> &lt; 0.003) and Hispanic ethnicity (<jats:italic toggle="yes">p</jats:italic> &lt; 0.008) were associated with lower mean Early Learning Composite score, but presenting symptoms and PICU course were not.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>Infants who survive critical pertussis often have neurodevelopmental deficits. These infants may benefit from routine neurodevelopmental screening.</jats:p> </jats:sec>