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Berger, John T.; Villalobos, Michele E.; Clark, Amy E.; Holubkov, Richard; Pollack, Murray M.; Berg, Robert A.; Carcillo, Joseph A.; Dalton, Heidi; Harrison, Rick; Meert, Kathleen L.; Newth, Christopher J. L.; Shanley, Thomas P.; Wessel, David L.; Anand, Kanwaljeet J. S.; Zimmerman, Jerry J.; Sanders, Ronald C.; Liu, Teresa; Burr, Jeri S.; Willson, Douglas F.; Doctor, Allan; Dean, J. Michael; Jenkins, Tammara L.; Nicholson, Carol E.

Cognitive Development One Year After Infantile Critical Pertussis*

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  • Medientyp: E-Artikel
  • Titel: Cognitive Development One Year After Infantile Critical Pertussis*
  • Beteiligte: Berger, John T.; Villalobos, Michele E.; Clark, Amy E.; Holubkov, Richard; Pollack, Murray M.; Berg, Robert A.; Carcillo, Joseph A.; Dalton, Heidi; Harrison, Rick; Meert, Kathleen L.; Newth, Christopher J. L.; Shanley, Thomas P.; Wessel, David L.; Anand, Kanwaljeet J. S.; Zimmerman, Jerry J.; Sanders, Ronald C.; Liu, Teresa; Burr, Jeri S.; Willson, Douglas F.; Doctor, Allan; Dean, J. Michael; Jenkins, Tammara L.; Nicholson, Carol E.
  • Erschienen: Ovid Technologies (Wolters Kluwer Health), 2018
  • Erschienen in: Pediatric Critical Care Medicine, 19 (2018) 2, Seite 89-97
  • Sprache: Englisch
  • DOI: 10.1097/pcc.0000000000001367
  • ISSN: 1529-7535
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Objectives: Pertussis can cause life-threatening illness in infants. Data regarding neurodevelopment after pertussis remain scant. The aim of this study was to assess cognitive development of infants with critical pertussis 1 year after PICU discharge. Design: Prospective cohort study. Setting: Eight hospitals comprising the Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network and 18 additional sites across the United States. Patients: Eligible patients had laboratory confirmation of pertussis infection, were less than 1 year old, and were admitted to the PICU for at least 24 hours. Interventions: The Mullen Scales of Early Learning was administered at a 1-year follow-up visit. Functional status was determined by examination and parental interview. Measurements and Main Results: Of 196 eligible patients, 111 (57%) completed the Mullen Scales of Early Learning. The mean scores for visual reception, receptive language, and expressive language domains were significantly lower than the norms (p < 0.001), but not fine and gross motor domains. Forty-one patients (37%) had abnormal scores in at least one domain and 10 (9%) had an Early Learning Composite score 2 or more sds below the population norms. Older age (p < 0.003) and Hispanic ethnicity (p < 0.008) were associated with lower mean Early Learning Composite score, but presenting symptoms and PICU course were not. Conclusions: Infants who survive critical pertussis often have neurodevelopmental deficits. These infants may benefit from routine neurodevelopmental screening.