Published in:
FEBS Letters, 436 (1998) 2, Seite 155-158
Language:
English
DOI:
10.1016/s0014-5793(98)01110-7
ISSN:
0014-5793;
1873-3468
Origination:
Footnote:
Description:
We have recently described a C825T polymorphism in the gene encoding for the Gβ3 subunit of heterotrimeric G proteins. The 825T allele is associated with a novel splice variant (Gβ3‐s) and enhanced signal transduction via pertussis toxin (PTX)‐sensitive G proteins. fMLP‐induced chemotaxis, but not O2− generation, was increased in neutrophils with the TC/TT (EC50=1.5±1.3 nM) genotypes compared to the CC genotype (EC50=5.9±1.5 nM). Maximal fMLP‐induced increase in [Ca2+]i was significantly reduced in neutrophils from individuals with TC/TT genotype vs. CC genotype (212.9±10.1 nM vs. 146.4±24.2 nM). Gβ3‐s appears to be associated with enhanced immune cell function in humans.