Beschreibung:
<jats:p>We have recently described a C825T polymorphism in the gene encoding for the Gβ3 subunit of heterotrimeric G proteins. The 825T allele is associated with a novel splice variant (Gβ3‐s) and enhanced signal transduction via pertussis toxin (PTX)‐sensitive G proteins. fMLP‐induced chemotaxis, but not O<jats:sup>2−</jats:sup> generation, was increased in neutrophils with the TC/TT (EC<jats:sub>50</jats:sub>=1.5±1.3 nM) genotypes compared to the CC genotype (EC<jats:sub>50</jats:sub>=5.9±1.5 nM). Maximal fMLP‐induced increase in [Ca<jats:sup>2+</jats:sup>]<jats:sub>i</jats:sub> was significantly reduced in neutrophils from individuals with TC/TT genotype vs. CC genotype (212.9±10.1 nM vs. 146.4±24.2 nM). Gβ3‐s appears to be associated with enhanced immune cell function in humans.</jats:p>