> Details

Buchholtz, Poul Erik; Ashkanian, Mahmoud; Hjerrild, Simon; Hauptmann, Line Kirstine; Devantier, Torben Albert; Jensen, Paulina; Wissing, Sanne; Thorgaard, Mette Viller; Bjerager, Laerke; Lund, Julie; Alrø, Anja Johnsen; Speed, Maria Simonsen; Brund, Rene Børge Korsgaard; Videbech, Poul

Low-frequency rTMS inhibits the anti-depressive effect of ECT. A pilot study

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Low-frequency rTMS inhibits the anti-depressive effect of ECT. A pilot study
  • Contributor: Buchholtz, Poul Erik; Ashkanian, Mahmoud; Hjerrild, Simon; Hauptmann, Line Kirstine; Devantier, Torben Albert; Jensen, Paulina; Wissing, Sanne; Thorgaard, Mette Viller; Bjerager, Laerke; Lund, Julie; Alrø, Anja Johnsen; Speed, Maria Simonsen; Brund, Rene Børge Korsgaard; Videbech, Poul
  • Published: Cambridge University Press (CUP), 2020
  • Published in: Acta Neuropsychiatrica, 32 (2020) 6, Seite 328-338
  • Language: English
  • DOI: 10.1017/neu.2020.28
  • ISSN: 0924-2708; 1601-5215
  • Keywords: Biological Psychiatry ; Psychiatry and Mental health
  • Origination:
  • Footnote:
  • Description: AbstractObjective:Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex has been shown to have a statistically and clinically significant anti-depressant effect. The present pilot study was carried out to investigate if right prefrontal low-frequency rTMS as an add-on to electroconvulsive therapy (ECT) accelerates the anti-depressant effect and reduces cognitive side effects.Methods:In this randomised, controlled, double-blind study, thirty-five patients with major depression were allocated to ECT+placebo or ECT+low-frequency right prefrontal rTMS. The severity of depression was evaluated during the course using the Hamilton scale for depression (the 17-item as well as the 6-item scale) and the major depression inventory (MDI). Furthermore, neuropsychological assessment of cognitive function was carried out.Results:The study revealed no significant difference between the two groups for any of the outcomes, but with a visible trend to lower scores for MDI after treatment in the placebo group. The negative impact of ECT on neurocognitive functions was short-lived, and scores on logical memory were significantly improved compared to baseline 4 weeks after last treatment. The ECT-rTMS group revealed generally less impairment of cognitive functions than the ECT-placebo group.Conclusion:The addition of low-frequency rTMS as an add-on to ECT treatment did not result in an accelerated response. On the contrary, the results suggest that low-frequency rTMS could inhibit the anti-depressant effect of ECT.