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Buchholtz, Poul Erik; Ashkanian, Mahmoud; Hjerrild, Simon; Hauptmann, Line Kirstine; Devantier, Torben Albert; Jensen, Paulina; Wissing, Sanne; Thorgaard, Mette Viller; Bjerager, Laerke; Lund, Julie; Alrø, Anja Johnsen; Speed, Maria Simonsen; Brund, Rene Børge Korsgaard; Videbech, Poul

Low-frequency rTMS inhibits the anti-depressive effect of ECT. A pilot study

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  • Medientyp: E-Artikel
  • Titel: Low-frequency rTMS inhibits the anti-depressive effect of ECT. A pilot study
  • Beteiligte: Buchholtz, Poul Erik; Ashkanian, Mahmoud; Hjerrild, Simon; Hauptmann, Line Kirstine; Devantier, Torben Albert; Jensen, Paulina; Wissing, Sanne; Thorgaard, Mette Viller; Bjerager, Laerke; Lund, Julie; Alrø, Anja Johnsen; Speed, Maria Simonsen; Brund, Rene Børge Korsgaard; Videbech, Poul
  • Erschienen: Cambridge University Press (CUP), 2020
  • Erschienen in: Acta Neuropsychiatrica
  • Sprache: Englisch
  • DOI: 10.1017/neu.2020.28
  • ISSN: 0924-2708; 1601-5215
  • Schlagwörter: Biological Psychiatry ; Psychiatry and Mental health
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec id="S0924270820000289_as1"><jats:title>Objective:</jats:title><jats:p>Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex has been shown to have a statistically and clinically significant anti-depressant effect. The present pilot study was carried out to investigate if right prefrontal low-frequency rTMS as an add-on to electroconvulsive therapy (ECT) accelerates the anti-depressant effect and reduces cognitive side effects.</jats:p></jats:sec><jats:sec id="S0924270820000289_as2"><jats:title>Methods:</jats:title><jats:p>In this randomised, controlled, double-blind study, thirty-five patients with major depression were allocated to ECT+placebo or ECT+low-frequency right prefrontal rTMS. The severity of depression was evaluated during the course using the Hamilton scale for depression (the 17-item as well as the 6-item scale) and the major depression inventory (MDI). Furthermore, neuropsychological assessment of cognitive function was carried out.</jats:p></jats:sec><jats:sec id="S0924270820000289_as3"><jats:title>Results:</jats:title><jats:p>The study revealed no significant difference between the two groups for any of the outcomes, but with a visible trend to lower scores for MDI after treatment in the placebo group. The negative impact of ECT on neurocognitive functions was short-lived, and scores on logical memory were significantly improved compared to baseline 4 weeks after last treatment. The ECT-rTMS group revealed generally less impairment of cognitive functions than the ECT-placebo group.</jats:p></jats:sec><jats:sec id="S0924270820000289_as4"><jats:title>Conclusion:</jats:title><jats:p>The addition of low-frequency rTMS as an add-on to ECT treatment did not result in an accelerated response. On the contrary, the results suggest that low-frequency rTMS could inhibit the anti-depressant effect of ECT.</jats:p></jats:sec>