> Details
Doenhardt, Maren;
Hufnagel, Markus;
Diffloth, Natalie;
Hübner, Johannes;
Mauer, René;
Schneider, Dominik T.;
Simon, Arne;
Tenenbaum, Tobias;
Trotter, Andreas;
Armann, Jakob;
Berner, Reinhard;
Abuleed, Aischa;
Achenbach, Michal;
Adamiak-Brych, Grazyna;
Aderhold, Martina;
Akanbi, Sandra;
Akmeinasi, Madaa;
Albers, Norbert;
Ammann-Schnell, Louisa;
Anders, Kristin;
Andree, Theresa;
Anhalt, Judith;
Apel, Nils;
Arens, Stefan;
[...]
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022
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- Media type: E-Article
- Title: Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022
- Contributor: Doenhardt, Maren; Hufnagel, Markus; Diffloth, Natalie; Hübner, Johannes; Mauer, René; Schneider, Dominik T.; Simon, Arne; Tenenbaum, Tobias; Trotter, Andreas; Armann, Jakob; Berner, Reinhard; Abuleed, Aischa; Achenbach, Michal; Adamiak-Brych, Grazyna; Aderhold, Martina; Akanbi, Sandra; Akmeinasi, Madaa; Albers, Norbert; Ammann-Schnell, Louisa; Anders, Kristin; Andree, Theresa; Anhalt, Judith; Apel, Nils; Arens, Stefan; [...]
- imprint: Springer Science and Business Media LLC, 2024
- Published in: Scientific Reports
- Language: English
- DOI: 10.1038/s41598-023-49210-1
- ISSN: 2045-2322
- Keywords: Multidisciplinary
- Origination:
- Footnote:
- Description: <jats:title>Abstract</jats:title><jats:p>By means of a nationwide, prospective, multicenter, observational cohort registry collecting data on 7375 patients with laboratory-confirmed SARS-CoV-2 admitted to children's hospitals in Germany, March 2020–November 2022, our study assessed the clinical features of children and adolescents hospitalized due to SARS-CoV-2, evaluated which of these patients might be at highest risk for severe COVID-19, and identified underlying risk factors. Outcomes tracked included: symptomatic infection, case fatality, sequelae at discharge and severe disease. Among reported cases, median age was one year, with 42% being infants. Half were admitted for reasons other than SARS-CoV-2. In 27%, preexisting comorbidities were present, most frequently obesity, neurological/neuromuscular disorders, premature birth, and respiratory, cardiovascular or gastrointestinal diseases. 3.0% of cases were admitted to ICU, but ICU admission rates varied as different SARS-CoV-2 variants gained prevalence. Main risk factors linked to ICU admission due to COVID-19 were: patient age (> 12 and 1–4 years old), obesity, neurological/neuromuscular diseases, Trisomy 21 or other genetic syndromes, and coinfections at time of hospitalization. With Omicron, the group at highest risk shifted to 1–4-year-olds. For both health care providers and the general public, understanding risk factors for severe disease is critical to informing decisions about risk-reduction measures, including vaccination and masking guidelines.</jats:p>
- Access State: Open Access