• Media type: E-Article
  • Title: Abstract 182: Mimetic peptide overcomes dysregulated L-Type Calcium Channel density and recovers myocardial function
  • Contributor: Rusconi, Francesca; Miragoli, Michele; Di Pasquale, Elisa; Rocchetti, Marcella; Ceriotti, Paola; Carullo, Pierluigi; Caprari, Silvia; Viggiani, Giacomo; Cazade, Magali; Chemin, Jean; Bang, Marie-Louise; Polticelli, Fabio; Zaza, Antonio; Condorelli, Gianluigi; Catalucci, Daniele
  • Published: Ovid Technologies (Wolters Kluwer Health), 2014
  • Published in: Circulation Research, 115 (2014) suppl_1
  • Language: English
  • DOI: 10.1161/res.115.suppl_1.182
  • ISSN: 0009-7330; 1524-4571
  • Origination:
  • Footnote:
  • Description: Voltage dependent L-Type calcium-channels (LTCCs) are located on the cardiomyocyte membrane and regulate cardiac contraction and rhythmicity. In human pathologies, such as heart failure (HF), decreased inward calcium current (I Ca ) is frequently observed. Here, we generated a mimetic peptide (MP) that targets LTCCs and restores impaired intracellular calcium homeostasis through a novel mechanism. Effective delivery of MP, fused with a cell penetrating peptide, was found to correct Ca2+ alterations in a mouse model of HF, in human cardiomyocytes derived from induced pluripotent stem-cells. These data provide a proof-of-concept supporting a therapeutic role for MP to treat human diseases related to LTCC abnormalities. Category: heart failure biology
  • Access State: Open Access