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Media type:
E-Article
Title:
Long noncoding RNA: a dazzling dancer in tumor immune microenvironment
Contributor:
Zhang, Yalu;
Liu, Qiaofei;
Liao, Quan
imprint:
Springer Science and Business Media LLC, 2020
Published in:
Journal of Experimental & Clinical Cancer Research, 39 (2020) 1
Language:
English
DOI:
10.1186/s13046-020-01727-3
ISSN:
1756-9966
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title><jats:p>Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that are highly linked to various cellular functions and pathological process. Emerging evidence indicates that lncRNAs participate in crosstalk between tumor and stroma, and reprogramming of tumor immune microenvironment (TIME). TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. However, hitherto, a comprehensive review aiming at relationship between lncRNAs and TIME is missing. In this review, we focus on the functional roles and molecular mechanisms of lncRNAs within the TIME. Furthermore, we discussed the potential immunotherapeutic strategies based on lncRNAs and their limitations.</jats:p>